| 1. Round | 23/01/2022 | Tigres FC | - | Real Cartagena | 1:2 | ||||
| 2. Round | 30/01/2022 | Real Santander | - | Tigres FC | 0:0 | ||||
| 3. Round | 05/02/2022 | Tigres FC | - | Atlético FC | 1:1 | ||||
| 4. Round | 13/02/2022 | Leones FC | - | Tigres FC | 3:1 | ||||
| 5. Round | 18/02/2022 | Tigres FC | - | Bogotá FC | 3:0 |  |
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| 6. Round | 26/02/2022 | Orsomarso SC | - | Tigres FC | 0:2 | ||||
| 7. Round | 06/03/2022 | Tigres FC | - | Llaneros FC | 0:1 |
Colombia