| 4. Round | 14/08/2021 | Jocoro FC | - | Isidro Metapán | 1:0 | ||||
| 5. Round | 22/08/2021 | Atlético Marte | - | Jocoro FC | 2:1 |  |
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| 6. Round | 25/08/2021 | Jocoro FC | - | Santa Tecla FC | 2:0 | ||||
| 7. Round | 29/08/2021 | CD Águila | - | Jocoro FC | 2:2 | ||||
| 8. Round | 11/09/2021 | Jocoro FC | - | AD Chalatenango | 3:1 | ||||
| 9. Round | 15/09/2021 | Jocoro FC | - | Municipal Limeño | 3:1 | ||||
| 10. Round | 19/09/2021 | Platense Zacatecoluca | - | Jocoro FC | 1:1 | ||||
| 11. Round | 25/09/2021 | Jocoro FC | - | Alianza | 3:3 | ||||
| 12. Round | 02/10/2021 | Jocoro FC | - | Luis Ángel Firpo | 2:1 | ||||
| 20. Round | 17/11/2021 | Municipal Limeño | - | Jocoro FC | 0:0 | ||||
| 21. Round | 21/11/2021 | Jocoro FC | - | Platense Zacatecoluca | 1:1 | ||||
| 22. Round | 27/11/2021 | Alianza | - | Jocoro FC | 2:0 |
El Salvador