| 3. Round | 07/08/2021 | Tigres FC | - | Orsomarso SC | 1:2 | ||||
| 4. Round | 15/08/2021 | Valledupar FC | - | Tigres FC | 0:0 | ||||
| 6. Round | 28/08/2021 | Fortaleza FC | - | Tigres FC | 2:1 | ||||
| 7. Round | 06/09/2021 | Tigres FC | - | Real Santander | 2:0 | ||||
| 8. Round | 10/09/2021 | Cortuluá | - | Tigres FC | 3:0 | ||||
| 9. Round | 22/09/2021 | Tigres FC | - | Unión Magdalena | 0:0 |
Colombia