| 1. Round | 09/07/2022 | Tigres FC | - | Fortaleza FC | 1:0 | ||||
| 2. Round | 16/07/2022 | Barranquilla FC | - | Tigres FC | 3:0 |  |
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| 4. Round | 30/07/2022 | Tigres FC | - | Leones FC | 1:1 | ||||
| 5. Round | 04/08/2022 | Boyacá Chicó | - | Tigres FC | 2:2 | ||||
| 13. Round | 18/09/2022 | Tigres FC | - | Boca Juniors de Cali | 3:2 | ||||
| 14. Round | 24/09/2022 | Llaneros FC | - | Tigres FC | 2:0 | ||||
| 15. Round | 01/10/2022 | Tigres FC | - | Bogotá FC | 2:1 | ||||
| 16. Round | 08/10/2022 | Cúcuta Deportivo | - | Tigres FC | 2:1 | |
Colombia