| 1. Round | 08/08/2021 | Honduras Progreso | - | Marathón | 1:2 | ||||
| 4. Round | 22/08/2021 | Honduras Progreso | - | Victoria | 2:0 | ||||
| 5. Round | 26/08/2021 | Olimpia | - | Honduras Progreso | 2:1 | ||||
| 6. Round | 29/08/2021 | Honduras Progreso | - | Vida | 1:1 | ||||
| 7. Round | 05/09/2021 | Honduras Progreso | - | Motagua | 0:3 | ||||
| 8. Round | 12/09/2021 | Real Sociedad | - | Honduras Progreso | 1:0 | ||||
| 9. Round | 16/09/2021 | Honduras Progreso | - | Real España | 1:1 | ||||
| 10. Round | 20/09/2021 | Vida | - | Honduras Progreso | 1:0 | ||||
| 11. Round | 23/09/2021 | Victoria | - | Honduras Progreso | 1:2 | ||||
| 15. Round | 24/10/2021 | Honduras Progreso | - | Olimpia | 0:2 | ||||
| 16. Round | 28/10/2021 | Real España | - | Honduras Progreso | 4:1 | ||||
| 17. Round | 01/11/2021 | Honduras Progreso | - | Real Sociedad | 2:1 | ||||
| 18. Round | 10/11/2021 | Motagua | - | Honduras Progreso | 3:2 |
Honduras