| 2. Round | 07/08/2022 | Honduras Progreso | - | Marathón | 0:2 |  |
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| 3. Round | 11/08/2022 | Honduras Progreso | - | Olancho FC | 2:2 | ||||
| 4. Round | 14/08/2022 | Lobos UPNFM | - | Honduras Progreso | 1:2 | ||||
| 5. Round | 21/08/2022 | Victoria | - | Honduras Progreso | 2:1 | ||||
| 8. Round | 04/09/2022 | Olimpia | - | Honduras Progreso | 1:1 | ||||
| 9. Round | 12/09/2022 | Real España | - | Honduras Progreso | 2:0 | ||||
| 10. Round | 18/09/2022 | Honduras Progreso | - | Motagua | 0:1 | ||||
| 11. Round | 01/10/2022 | Marathón | - | Honduras Progreso | 5:1 | ||||
| 12. Round | 09/10/2022 | Olancho FC | - | Honduras Progreso | 2:1 | ||||
| 13. Round | 16/10/2022 | Honduras Progreso | - | Lobos UPNFM | 2:2 | |
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| 14. Round | 20/10/2022 | Honduras Progreso | - | Victoria | 2:2 | ||||
| 16. Round | 06/11/2022 | Real Sociedad | - | Honduras Progreso | 2:2 | ||||
| 17. Round | 13/11/2022 | Honduras Progreso | - | Olimpia | 1:2 | ||||
| 18. Round | 19/11/2022 | Honduras Progreso | - | Real España | 0:0 |
Honduras