| 2. Round | 02/08/2021 | Pirin Blagoevgrad | - | PFC Beroe | 2:3 | ||||
| 4. Round | 13/08/2021 | Pirin Blagoevgrad | - | CSKA 1948 Sofia | 4:1 | ||||
| 5. Round | 22/08/2021 | CSKA Sofia | - | Pirin Blagoevgrad | 1:0 | ||||
| 9. Round | 27/09/2021 | Pirin Blagoevgrad | - | Cherno More Varna | 2:2 |  |
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| 11. Round | 15/10/2021 | Pirin Blagoevgrad | - | Botev Vratsa | 3:1 | ||||
| 13. Round | 31/10/2021 | Pirin Blagoevgrad | - | Tsarsko Selo Sofia | 2:1 | ||||
| 14. Round | 06/11/2021 | Pirin Blagoevgrad | - | Botev Plovdiv | 0:1 | ||||
| 15. Round | 19/11/2021 | PFC Beroe | - | Pirin Blagoevgrad | 1:1 | ||||
| 16. Round | 27/11/2021 | Pirin Blagoevgrad | - | Lokomotiv Plovdiv | 2:3 | ||||
| 17. Round | 02/12/2021 | CSKA 1948 Sofia | - | Pirin Blagoevgrad | 1:0 | ||||
| 18. Round | 05/12/2021 | Pirin Blagoevgrad | - | CSKA Sofia | 1:1 | ||||
| 20. Round | 21/02/2022 | Pirin Blagoevgrad | - | Lokomotiv Sofia | 2:1 | ||||
| 21. Round | 28/02/2022 | Pirin Blagoevgrad | - | Arda Kardzhali | 1:0 | ||||
| 22. Round | 05/03/2022 | Cherno More Varna | - | Pirin Blagoevgrad | 1:1 | ||||
| 23. Round | 14/03/2022 | Pirin Blagoevgrad | - | Slavia Sofia | 0:0 | ||||
| 24. Round | 20/03/2022 | Botev Vratsa | - | Pirin Blagoevgrad | 0:3 |
Bulgaria