| 2. Round | 26/01/2022 | Deportivo Cali | - | Deportes Tolima | 0:1 |  |
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| 4. Round | 04/02/2022 | Atlético Nacional | - | Deportes Tolima | 0:1 | |
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| 5. Round | 06/02/2022 | Deportes Tolima | - | Atlético Bucaramanga | 2:1 | ||||
| 6. Round | 14/02/2022 | Jaguares de Córdoba | - | Deportes Tolima | 0:2 | ||||
| 7. Round | 16/02/2022 | Deportes Tolima | - | Santa Fe | 3:0 | ||||
| 9. Round | 26/02/2022 | Deportes Tolima | - | Atlético Junior | 0:2 | ||||
| 15. Round | 09/04/2022 | Deportes Tolima | - | Águilas Doradas | 3:0 | ||||
| 19. Round | 09/05/2022 | Millonarios | - | Deportes Tolima | 0:0 | |
Colombia