| 1. Round | 11/07/2022 | Deportes Tolima | - | Independiente Medellín | 1:1 | ||||
| 5. Round | 02/08/2022 | Atlético Bucaramanga | - | Deportes Tolima | 2:1 | ||||
| 6. Round | 06/08/2022 | Deportes Tolima | - | Jaguares de Córdoba | 2:2 |  |
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| 7. Round | 13/08/2022 | Santa Fe | - | Deportes Tolima | 2:1 | ||||
| 8. Round | 22/08/2022 | Deportes Tolima | - | La Equidad | 1:1 | ||||
| 9. Round | 29/08/2022 | Atlético Junior | - | Deportes Tolima | 2:1 |  |
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| 11. Round | 10/09/2022 | Patriotas FC | - | Deportes Tolima | 1:1 | ||||
| 12. Round | 17/09/2022 | Deportes Tolima | - | Once Caldas | 1:0 | ||||
| 13. Round | 22/09/2022 | América de Cali | - | Deportes Tolima | 0:0 | ||||
| 14. Round | 26/09/2022 | Deportes Tolima | - | Deportivo Pereira | 1:3 | ||||
| 15. Round | 02/10/2022 | Águilas Doradas | - | Deportes Tolima | 1:2 | ||||
| 16. Round | 09/10/2022 | Deportivo Pasto | - | Deportes Tolima | 2:1 | |
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| 19. Round | 23/10/2022 | Deportes Tolima | - | Millonarios | 1:0 |
Colombia