| 1. Round | 17/07/2018 | 3 de Febrero | - | General Díaz | 1:1 | ||||
| 2. Round | 21/07/2018 | General Díaz | - | Club Olimpia | 1:1 | ||||
| 4. Round | 05/08/2018 | Deportivo Santaní | - | General Díaz | 3:1 | ||||
| 6. Round | 20/08/2018 | Deportivo Capiatá | - | General Díaz | 3:1 | ||||
| 7. Round | 25/08/2018 | General Díaz | - | Cerro Porteño | 1:4 | ||||
| 10. Round | 15/09/2018 | Libertad | - | General Díaz | 1:0 | ||||
| 13. Round | 07/10/2018 | Club Olimpia | - | General Díaz | 2:2 |  |
|||
| 14. Round | 14/10/2018 | General Díaz | - | Club Nacional | 1:2 | ||||
| 15. Round | 20/10/2018 | General Díaz | - | Deportivo Santaní | 4:0 | |
|||
| 16. Round | 28/10/2018 | Sportivo Luqueño | - | General Díaz | 2:0 | ||||
| 17. Round | 02/11/2018 | General Díaz | - | Deportivo Capiatá | 2:3 | ||||
| 18. Round | 11/11/2018 | Cerro Porteño | - | General Díaz | 3:1 | ||||
| 19. Round | 18/11/2018 | General Díaz | - | Independiente CG | 2:1 | |
|||
| 20. Round | 23/11/2018 | Guaraní | - | General Díaz | 0:2 | ||||
| 21. Round | 01/12/2018 | General Díaz | - | Libertad | 1:1 | |
|||
| 22. Round | 08/12/2018 | Sol de América | - | General Díaz | 1:0 |
Paraguay