5. Round | 11/09/2021 | CD Santa Clara | - | SL Benfica | 0:5 | ||||
6. Round | 17/09/2021 | Portimonense SC | - | CD Santa Clara | 2:1 | ||||
7. Round | 26/09/2021 | CD Santa Clara | - | Sporting Braga | 1:1 | ||||
9. Round | 23/10/2021 | CD Santa Clara | - | FC Famalicão | 0:2 | ||||
11. Round | 07/11/2021 | CD Santa Clara | - | FC Porto | 0:3 | ||||
12. Round | 29/11/2021 | GD Estoril | - | CD Santa Clara | 2:2 | ||||
13. Round | 05/12/2021 | CD Santa Clara | - | FC Arouca | 2:1 | ||||
16. Round | 30/12/2021 | Paços de Ferreira | - | CD Santa Clara | 2:1 | ||||
17. Round | 07/01/2022 | CD Santa Clara | - | Sporting CP | 3:2 | ||||
18. Round | 16/01/2022 | CD Santa Clara | - | CD Tondela | 2:2 | ||||
20. Round | 01/02/2022 | CD Santa Clara | - | Boavista | 2:1 | ||||
21. Round | 06/02/2022 | Gil Vicente | - | CD Santa Clara | 2:2 | ||||
23. Round | 21/02/2022 | CD Santa Clara | - | Portimonense SC | 1:1 | ||||
28. Round | 04/04/2022 | FC Porto | - | CD Santa Clara | 3:0 | ||||
34. Round | 14/05/2022 | Sporting CP | - | CD Santa Clara | 4:0 |