| 1. Round | 17/08/2018 | NEC Nijmegen | - | SC Cambuur | 2:2 | ||||
| 2. Round | 24/08/2018 | SC Cambuur | - | AZ Alkmaar (J) | 2:1 |  |
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| 3. Round | 31/08/2018 | TOP Oss | - | SC Cambuur | 1:3 | ||||
| 4. Round | 07/09/2018 | SC Cambuur | - | RKC Waalwijk | 2:0 | |
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| 5. Round | 14/09/2018 | SC Cambuur | - | Telstar | 2:0 | |
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| 6. Round | 21/09/2018 | FC Utrecht (J) | - | SC Cambuur | 0:0 | ||||
| 7. Round | 28/09/2018 | SC Cambuur | - | Roda JC Kerkrade | 0:1 | ||||
| 8. Round | 05/10/2018 | FC Dordrecht | - | SC Cambuur | 3:1 | |
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| 9. Round | 14/10/2018 | Sparta Rotterdam | - | SC Cambuur | 3:0 | ||||
| 10. Round | 19/10/2018 | SC Cambuur | - | Helmond Sport | 3:1 | ||||
| 11. Round | 26/10/2018 | Go Ahead Eagles | - | SC Cambuur | 2:0 | ||||
| 12. Round | 02/11/2018 | SC Cambuur | - | Jong Ajax | 2:1 | |
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| 14. Round | 17/11/2018 | SC Cambuur | - | FC Volendam | 1:1 | ||||
| 15. Round | 23/11/2018 | FC Den Bosch | - | SC Cambuur | 1:1 | ||||
| 16. Round | 30/11/2018 | SC Cambuur | - | FC Eindhoven | 1:3 |
Netherlands