| 5. Round | 09/02/2022 | AD Guanacasteca | - | Municipal Pérez Zeledón | 0:0 | ||||
| 7. Round | 20/02/2022 | Municipal Pérez Zeledón | - | Deportivo Saprissa | 0:0 | ||||
| 11. Round | 01/04/2022 | CS Herediano | - | Municipal Pérez Zeledón | 3:2 | ||||
| 12. Round | 05/04/2022 | Municipal Grecia | - | Municipal Pérez Zeledón | 2:0 | ||||
| 13. Round | 11/04/2022 | Municipal Pérez Zeledón | - | CS Cartaginés | 3:0 |  |
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| 15. Round | 20/04/2022 | LD Alajuelense | - | Municipal Pérez Zeledón | 3:1 |  |
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| 16. Round | 24/04/2022 | Municipal Pérez Zeledón | - | AD Guanacasteca | 2:2 | ||||
| 17. Round | 27/04/2022 | Municipal Pérez Zeledón | - | Santos de Guápiles | 1:1 | ||||
| 18. Round | 01/05/2022 | Deportivo Saprissa | - | Municipal Pérez Zeledón | 2:1 | |
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| 19. Round | 05/05/2022 | Municipal Pérez Zeledón | - | Sporting FC | 0:1 | ||||
| 20. Round | 08/05/2022 | Guadalupe | - | Municipal Pérez Zeledón | 2:2 | |
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| 21. Round | 11/05/2022 | Jicaral | - | Municipal Pérez Zeledón | 2:1 | ||||
| 22. Round | 15/05/2022 | Municipal Pérez Zeledón | - | CS Herediano | 2:3 | |
Costa Rica