1. Round | 01/08/2021 | Managua FC | - | Juventus Managua | 0:1 | ||||
2. Round | 09/08/2021 | ART Municipal Jalapa | - | Managua FC | 1:1 | ||||
4. Round | 22/08/2021 | H&H Export Sébaco | - | Managua FC | 0:0 | ||||
5. Round | 30/08/2021 | Managua FC | - | Diriangén FC | 1:2 | ||||
6. Round | 23/09/2021 | Managua FC | - | Club Deportivo Ocotal | 3:1 | ||||
12. Round | 17/10/2021 | Real Estelí FC | - | Managua FC | 1:0 | ||||
13. Round | 21/10/2021 | Managua FC | - | H&H Export Sébaco | 1:2 |