| 1. Round | 23/07/2022 | Sporting San Miguelito | - | Alianza | 0:1 | ||||
| 2. Round | 31/07/2022 | Plaza Amador | - | Sporting San Miguelito | 1:1 | ||||
| 3. Round | 08/08/2022 | Sporting San Miguelito | - | Árabe Unido | 0:0 | ||||
| 4. Round | 11/08/2022 | Sporting San Miguelito | - | Tauro FC | 3:1 | ||||
| 5. Round | 14/08/2022 | Potros del Este | - | Sporting San Miguelito | 1:3 | ||||
| 6. Round | 21/08/2022 | Sporting San Miguelito | - | UD Universitario | 2:2 | ||||
| 7. Round | 28/08/2022 | Herrera FC | - | Sporting San Miguelito | 0:0 | ||||
| 8. Round | 03/09/2022 | Sporting San Miguelito | - | Veraguas United | 3:2 | ||||
| 15. Round | 17/10/2022 | Tauro FC | - | Sporting San Miguelito | 2:0 | ||||
| 16. Round | 22/10/2022 | Sporting San Miguelito | - | Potros del Este | 3:2 |
Panama