| 11. Round | 20/11/2021 | SuperSport United | - | Marumo Gallants | 1:2 | ||||
| 19. Round | 24/11/2021 | Mamelodi Sundowns | - | SuperSport United | 2:2 | ||||
| 13. Round | 05/12/2021 | SuperSport United | - | Sekhukhune United | 0:1 | ||||
| 14. Round | 08/12/2021 | Stellenbosch FC | - | SuperSport United | 0:1 | ||||
| 15. Round | 11/12/2021 | SuperSport United | - | Mamelodi Sundowns | 0:1 |  |
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| 16. Round | 18/12/2021 | Sekhukhune United | - | SuperSport United | 0:0 | ||||
| 17. Round | 22/12/2021 | SuperSport United | - | Cape Town City FC | 3:2 |  |
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| 21. Round | 05/03/2022 | SuperSport United | - | AmaZulu FC | 2:0 | |
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| 12. Round | 16/03/2022 | Orlando Pirates | - | SuperSport United | 3:2 | |
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| 22. Round | 19/03/2022 | TS Galaxy | - | SuperSport United | 1:1 | |
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| 23. Round | 02/04/2022 | Golden Arrows | - | SuperSport United | 3:2 | ||||
| 24. Round | 05/04/2022 | SuperSport United | - | Chippa United | 1:1 | ||||
| 25. Round | 16/04/2022 | Kaizer Chiefs | - | SuperSport United | 0:1 | ||||
| 26. Round | 23/04/2022 | Marumo Gallants | - | SuperSport United | 0:0 | |
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| 28. Round | 06/05/2022 | SuperSport United | - | Moroka Swallows | 2:2 | |
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| 30. Round | 30/05/2022 | SuperSport United | - | Orlando Pirates | 2:0 |
South Africa