| 7. Round | 03/09/2022 | Newport County | - | Grimsby Town | 0:2 | ||||
| 9. Round | 13/09/2022 | Grimsby Town | - | Gillingham FC | 1:1 | ||||
| 4. Round | 27/09/2022 | Grimsby Town | - | Carlisle United | 1:2 | ||||
| 13. Round | 25/10/2022 | Barrow AFC | - | Grimsby Town | 1:0 | ||||
| 17. Round | 29/10/2022 | Hartlepool United | - | Grimsby Town | 2:1 | ||||
| 18. Round | 12/11/2022 | Grimsby Town | - | Doncaster Rovers | 1:3 | ||||
| 19. Round | 19/11/2022 | Grimsby Town | - | Stevenage FC | 1:1 | ||||
| 20. Round | 03/12/2022 | AFC Wimbledon | - | Grimsby Town | 1:0 |  |
England