| 2. Round | 07/08/2015 | Waldhof Mannheim | - | 1899 Hoffenheim II | 3:1 | ||||
| 3. Round | 14/08/2015 | FC 08 Homburg | - | 1899 Hoffenheim II | 2:2 | ||||
| 5. Round | 26/08/2015 | SpVgg Neckarelz | - | 1899 Hoffenheim II | 2:4 | ||||
| 6. Round | 30/08/2015 | 1899 Hoffenheim II | - | FC-Astoria Walldorf | 2:3 | ||||
| 7. Round | 05/09/2015 | 1. FC Kaiserslautern II | - | 1899 Hoffenheim II | 0:0 | ||||
| 10. Round | 27/09/2015 | 1899 Hoffenheim II | - | Hessen Kassel | 2:2 | ||||
| 11. Round | 04/10/2015 | Kickers Offenbach | - | 1899 Hoffenheim II | 1:1 | ||||
| 15. Round | 31/10/2015 | FK Pirmasens | - | 1899 Hoffenheim II | 0:1 | ||||
| 20. Round | 28/02/2016 | 1899 Hoffenheim II | - | FC 08 Homburg | 4:0 | ||||
| 24. Round | 22/03/2016 | 1899 Hoffenheim II | - | 1. FC Kaiserslautern II | 1:1 | ||||
| 25. Round | 26/03/2016 | Bahlinger SC | - | 1899 Hoffenheim II | 2:3 | ||||
| 26. Round | 02/04/2016 | 1899 Hoffenheim II | - | 1. FC Saarbrücken | 4:1 | ||||
| 21. Round | 05/04/2016 | Eintracht Trier | - | 1899 Hoffenheim II | 1:2 | ||||
| 31. Round | 06/05/2016 | Wormatia Worms | - | 1899 Hoffenheim II | 0:2 | ||||
| 32. Round | 11/05/2016 | 1899 Hoffenheim II | - | FK Pirmasens | 1:0 |
Germany