| 2. Round | 23/01/2022 | Isidro Metapán | - | AD Chalatenango | 2:1 | ||||
| 3. Round | 27/01/2022 | Alianza | - | AD Chalatenango | 3:1 | ||||
| 4. Round | 30/01/2022 | AD Chalatenango | - | Luis Ángel Firpo | 2:1 | ||||
| 5. Round | 06/02/2022 | Platense Zacatecoluca | - | AD Chalatenango | 1:1 |  |
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| 6. Round | 10/02/2022 | AD Chalatenango | - | Once Municipal | 1:0 | ||||
| 7. Round | 13/02/2022 | CD Águila | - | AD Chalatenango | 0:1 | |
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| 8. Round | 20/02/2022 | AD Chalatenango | - | Jocoro FC | 1:0 | ||||
| 9. Round | 23/02/2022 | FAS | - | AD Chalatenango | 1:3 | |
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| 10. Round | 27/02/2022 | AD Chalatenango | - | Santa Tecla FC | 1:0 | ||||
| 12. Round | 12/03/2022 | Atlético Marte | - | AD Chalatenango | 4:2 | ||||
| 13. Round | 20/03/2022 | AD Chalatenango | - | Isidro Metapán | 1:1 |
Jamaica