| 1. Round | 14/08/2021 | Fatih Karagümrük | - | Gaziantep FK | 3:2 | ||||
| 2. Round | 21/08/2021 | Gaziantep FK | - | Beşiktaş | 0:0 | ||||
| 3. Round | 28/08/2021 | Yeni Malatyaspor | - | Gaziantep FK | 2:0 | ||||
| 5. Round | 18/09/2021 | Sivasspor | - | Gaziantep FK | 1:1 | ||||
| 6. Round | 22/09/2021 | Gaziantep FK | - | İstanbul Başakşehir | 1:0 | ||||
| 7. Round | 25/09/2021 | Adana Demirspor | - | Gaziantep FK | 4:0 | ||||
| 9. Round | 18/10/2021 | Hatayspor | - | Gaziantep FK | 2:1 |  |
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| 10. Round | 23/10/2021 | Gaziantep FK | - | Giresunspor | 1:1 | ||||
| 15. Round | 06/12/2021 | Göztepe | - | Gaziantep FK | 2:1 | |
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| 16. Round | 13/12/2021 | Gaziantep FK | - | Fenerbahçe | 3:2 | ||||
| 17. Round | 19/12/2021 | Kayserispor | - | Gaziantep FK | 0:0 |
Cyprus