| 1. Round | 02/08/2021 | ART Municipal Jalapa | - | Club Deportivo Ocotal | 1:1 | ||||
| 2. Round | 09/08/2021 | ART Municipal Jalapa | - | Managua FC | 1:1 | ||||
| 3. Round | 15/08/2021 | UNAN Managua | - | ART Municipal Jalapa | 1:0 | ||||
| 4. Round | 22/08/2021 | ART Municipal Jalapa | - | CD Walter Ferretti | 2:0 |  |
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| 5. Round | 30/08/2021 | Real Estelí FC | - | ART Municipal Jalapa | 2:0 | ||||
| 6. Round | 03/09/2021 | ART Municipal Jalapa | - | H&H Export Sébaco | 0:2 | ||||
| 7. Round | 12/09/2021 | Real Madriz | - | ART Municipal Jalapa | 1:0 | ||||
| 8. Round | 20/09/2021 | Juventus Managua | - | ART Municipal Jalapa | 3:1 | ||||
| 9. Round | 27/09/2021 | ART Municipal Jalapa | - | Diriangén FC | 2:1 | ||||
| 10. Round | 03/10/2021 | Club Deportivo Ocotal | - | ART Municipal Jalapa | 0:0 | ||||
| 12. Round | 18/10/2021 | ART Municipal Jalapa | - | UNAN Managua | 2:2 | ||||
| 13. Round | 21/10/2021 | CD Walter Ferretti | - | ART Municipal Jalapa | 5:0 |
Nicaragua