| 1. Round | 20/08/2021 | Mamelodi Sundowns | - | AmaZulu FC | 1:0 | ||||
| 12. Round | 27/11/2021 | Mamelodi Sundowns | - | Sekhukhune United | 2:0 | ||||
| 13. Round | 04/12/2021 | Stellenbosch FC | - | Mamelodi Sundowns | 1:1 | ||||
| 14. Round | 08/12/2021 | Mamelodi Sundowns | - | Royal AM | 3:2 | ||||
| 18. Round | 07/02/2022 | Mamelodi Sundowns | - | Chippa United | 2:0 | ||||
| 20. Round | 02/03/2022 | TS Galaxy | - | Mamelodi Sundowns | 0:3 | ||||
| 21. Round | 05/03/2022 | Maritzburg United | - | Mamelodi Sundowns | 2:1 | ||||
| 30. Round | 23/05/2022 | Royal AM | - | Mamelodi Sundowns | 2:3 |  |
Zambia