1. Round | 22/01/2022 | Diriangén FC | - | UNAN Managua | 4:0 | ||||
6. Round | 28/02/2022 | Managua FC | - | UNAN Managua | 3:3 | ||||
7. Round | 04/03/2022 | Real Estelí FC | - | UNAN Managua | 3:0 | ||||
11. Round | 19/03/2022 | UNAN Managua | - | H&H Export Sébaco | 3:3 | ||||
12. Round | 04/04/2022 | ART Municipal Jalapa | - | UNAN Managua | 1:1 | ||||
14. Round | 11/04/2022 | CD Walter Ferretti | - | UNAN Managua | 4:1 | ||||
18. Round | 01/05/2022 | Juventus Managua | - | UNAN Managua | 1:3 |