| 19. Round | 21/01/2022 | US Avranches | - | FC Sète | 2:1 | ||||
| 17. Round | 29/01/2022 | US Avranches | - | Le Mans FC | 0:1 | ||||
| 21. Round | 11/02/2022 | US Avranches | - | CS Sedan | 0:3 | ||||
| 22. Round | 18/02/2022 | Stade Lavallois | - | US Avranches | 0:0 | ||||
| 23. Round | 25/02/2022 | US Avranches | - | US Concarneau | 1:1 | ||||
| 24. Round | 05/03/2022 | US Boulogne | - | US Avranches | 1:2 | ||||
| 25. Round | 11/03/2022 | US Avranches | - | FC Chambly | 1:0 | ||||
| 26. Round | 18/03/2022 | Red Star FC | - | US Avranches | 2:1 | ||||
| 27. Round | 25/03/2022 | US Avranches | - | US Orléans | 1:2 | ||||
| 28. Round | 01/04/2022 | FC Annecy | - | US Avranches | 4:1 | ||||
| 31. Round | 22/04/2022 | US Avranches | - | SO Cholet | 0:2 | ||||
| 34. Round | 13/05/2022 | US Avranches | - | US Créteil-Lusitanos | 2:1 |
France
Guadeloupe