| 11. Round | 26/09/2021 | Isidro Metapán | - | AD Chalatenango | 1:4 |  |
 |
||
| 12. Round | 02/10/2021 | Platense Zacatecoluca | - | AD Chalatenango | 2:1 | |
|||
| 13. Round | 18/10/2021 | AD Chalatenango | - | Atlético Marte | 2:2 | ||||
| 14. Round | 21/10/2021 | Alianza | - | AD Chalatenango | 1:0 | ||||
| 15. Round | 24/10/2021 | AD Chalatenango | - | Santa Tecla FC | 0:2 | ||||
| 16. Round | 31/10/2021 | Luis Ángel Firpo | - | AD Chalatenango | 4:2 | ||||
| 17. Round | 03/11/2021 | AD Chalatenango | - | CD Águila | 1:1 | ||||
| 18. Round | 07/11/2021 | Once Municipal | - | AD Chalatenango | 1:2 | |
|
Jamaica