| 11. Round | 01/04/2022 | CS Herediano | - | Municipal Pérez Zeledón | 3:2 |  |
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| 12. Round | 05/04/2022 | Municipal Grecia | - | Municipal Pérez Zeledón | 2:0 | ||||
| 13. Round | 11/04/2022 | Municipal Pérez Zeledón | - | CS Cartaginés | 3:0 | ||||
| 14. Round | 14/04/2022 | Municipal Pérez Zeledón | - | AD San Carlos | 1:0 | |
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| 15. Round | 20/04/2022 | LD Alajuelense | - | Municipal Pérez Zeledón | 3:1 | ||||
| 19. Round | 05/05/2022 | Municipal Pérez Zeledón | - | Sporting FC | 0:1 | ||||
| 20. Round | 08/05/2022 | Guadalupe | - | Municipal Pérez Zeledón | 2:2 | ||||
| 21. Round | 11/05/2022 | Jicaral | - | Municipal Pérez Zeledón | 2:1 |
Costa Rica