| 3. Round | 04/08/2021 | FAS | - | Jocoro FC | 4:1 | ||||
| 4. Round | 15/08/2021 | Municipal Limeño | - | FAS | 0:3 | ||||
| 5. Round | 22/08/2021 | FAS | - | Platense Zacatecoluca | 0:1 | ||||
| 6. Round | 26/08/2021 | Alianza | - | FAS | 1:0 |  |
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| 7. Round | 29/08/2021 | FAS | - | Luis Ángel Firpo | 3:1 | |
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| 8. Round | 12/09/2021 | Once Municipal | - | FAS | 1:3 | |
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| 9. Round | 16/09/2021 | AD Chalatenango | - | FAS | 1:2 | |
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| 13. Round | 18/10/2021 | FAS | - | CD Águila | 0:1 | ||||
| 16. Round | 30/10/2021 | Platense Zacatecoluca | - | FAS | 0:0 | |
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| 18. Round | 07/11/2021 | Luis Ángel Firpo | - | FAS | 2:0 |
El Salvador