| 1. Round | 21/08/2021 | Paphos FC | - | APOEL Nikosia | 4:0 | ||||
| 2. Round | 13/09/2021 | AEL Limassol | - | Paphos FC | 4:0 | ||||
| 3. Round | 18/09/2021 | Paphos FC | - | AEK Larnaca | 1:1 | ||||
| 5. Round | 02/10/2021 | Paphos FC | - | Doxa Katokopias | 1:1 | ||||
| 8. Round | 01/11/2021 | Paphos FC | - | PAEEK | 2:0 | ||||
| 9. Round | 07/11/2021 | Anorthosis Famagusta | - | Paphos FC | 1:0 | ||||
| 10. Round | 20/11/2021 | Paphos FC | - | Ethnikos Achna | 3:0 | ||||
| 15. Round | 05/01/2022 | Paphos FC | - | Omonia Nikosia | 1:1 |
France