| 2. Round | 20/08/2021 | Samsunspor | - | Balıkesirspor | 3:1 | ||||
| 3. Round | 28/08/2021 | Kocaelispor | - | Samsunspor | 1:0 | ||||
| 4. Round | 12/09/2021 | Samsunspor | - | Keçiörengücü | 2:0 | ||||
| 5. Round | 15/09/2021 | Bursaspor | - | Samsunspor | 4:1 |  |
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| 7. Round | 27/09/2021 | Denizlispor | - | Samsunspor | 2:3 | ||||
| 8. Round | 03/10/2021 | Samsunspor | - | Ümraniyespor | 1:1 | ||||
| 9. Round | 16/10/2021 | Menemen Belediyespor | - | Samsunspor | 3:2 | ||||
| 10. Round | 23/10/2021 | Samsunspor | - | BB Erzurumspor | 0:0 | ||||
| 11. Round | 30/10/2021 | Bandırmaspor | - | Samsunspor | 2:0 |
France