| 1. Round | 09/07/2022 | Real Santander | - | Llaneros FC | 3:1 | ||||
| 2. Round | 17/07/2022 | Deportes Quindío | - | Real Santander | 2:0 | ||||
| 3. Round | 23/07/2022 | Real Santander | - | Fortaleza FC | 1:0 | ||||
| 4. Round | 30/07/2022 | Real Santander | - | Atlético FC | 0:1 | ||||
| 5. Round | 05/08/2022 | Leones FC | - | Real Santander | 1:1 | ||||
| 6. Round | 08/08/2022 | Real Santander | - | Bogotá FC | 2:0 | ||||
| 7. Round | 17/08/2022 | Real Cartagena | - | Real Santander | 2:2 | ||||
| 8. Round | 20/08/2022 | Orsomarso SC | - | Real Santander | 0:0 | ||||
| 9. Round | 27/08/2022 | Real Santander | - | Cúcuta Deportivo | 0:1 |
Colombia