| 1. Round | 28/07/2021 | Municipal Pérez Zeledón | - | Jicaral | 1:1 | ||||
| 2. Round | 01/08/2021 | Jicaral | - | CS Herediano | 3:2 | ||||
| 3. Round | 08/08/2021 | Municipal Grecia | - | Jicaral | 0:0 | ||||
| 5. Round | 14/08/2021 | AD San Carlos | - | Jicaral | 0:0 | ||||
| 6. Round | 21/08/2021 | Jicaral | - | Santos de Guápiles | 1:1 |  |
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| 7. Round | 25/08/2021 | Deportivo Saprissa | - | Jicaral | 4:0 | ||||
| 8. Round | 28/08/2021 | Jicaral | - | Guadalupe | 0:0 | ||||
| 4. Round | 01/09/2021 | Jicaral | - | Sporting FC | 1:3 | ||||
| 9. Round | 08/09/2021 | LD Alajuelense | - | Jicaral | 2:0 | ||||
| 10. Round | 12/09/2021 | AD Guanacasteca | - | Jicaral | 1:1 | ||||
| 11. Round | 15/09/2021 | Jicaral | - | CS Cartaginés | 0:3 | ||||
| 12. Round | 18/09/2021 | Jicaral | - | Municipal Pérez Zeledón | 3:0 | ||||
| 13. Round | 26/09/2021 | CS Herediano | - | Jicaral | 1:0 | ||||
| 14. Round | 02/10/2021 | Jicaral | - | Municipal Grecia | 3:1 | ||||
| 15. Round | 12/10/2021 | Sporting FC | - | Jicaral | 2:1 | ||||
| 16. Round | 17/10/2021 | Jicaral | - | AD San Carlos | 0:4 | ||||
| 20. Round | 21/11/2021 | Jicaral | - | LD Alajuelense | 0:3 | ||||
| 21. Round | 24/11/2021 | Jicaral | - | AD Guanacasteca | 2:2 | ||||
| 22. Round | 28/11/2021 | CS Cartaginés | - | Jicaral | 4:0 |
Costa Rica