| 2. Round | 13/02/2022 | Herrera FC | - | Veraguas United | 2:0 |  |
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| 3. Round | 19/02/2022 | Independiente de La Chorrera | - | Herrera FC | 1:2 | ||||
| 4. Round | 27/02/2022 | Herrera FC | - | Atlético Chiriquí | 1:2 | ||||
| 5. Round | 05/03/2022 | Herrera FC | - | San Francisco FC | 0:0 | ||||
| 6. Round | 09/03/2022 | Herrera FC | - | Tauro FC | 0:0 | ||||
| 7. Round | 13/03/2022 | Sporting San Miguelito | - | Herrera FC | 1:1 | ||||
| 9. Round | 26/03/2022 | Plaza Amador | - | Herrera FC | 1:1 | ||||
| 10. Round | 02/04/2022 | Herrera FC | - | Potros del Este | 1:2 | ||||
| 14. Round | 28/04/2022 | Herrera FC | - | Independiente de La Chorrera | 4:0 | ||||
| 12. Round | 05/05/2022 | Herrera FC | - | UD Universitario | 3:1 | |
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| 16. Round | 08/05/2022 | San Francisco FC | - | Herrera FC | 3:1 |
Panama