| 1. Round | 20/08/2021 | AEK Larnaca | - | Doxa Katokopias | 1:1 |  |
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| 6. Round | 18/10/2021 | Doxa Katokopias | - | Aris Limassol | 1:2 | ||||
| 7. Round | 22/10/2021 | Olympiakos Nikosia | - | Doxa Katokopias | 1:0 | ||||
| 8. Round | 30/10/2021 | Doxa Katokopias | - | APOEL Nikosia | 2:2 | ||||
| 9. Round | 05/11/2021 | Apollon Limassol | - | Doxa Katokopias | 3:0 | ||||
| 10. Round | 21/11/2021 | Doxa Katokopias | - | AEL Limassol | 0:0 | ||||
| 11. Round | 27/11/2021 | PAEEK | - | Doxa Katokopias | 1:2 | |
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| 12. Round | 04/12/2021 | Doxa Katokopias | - | AEK Larnaca | 1:4 | ||||
| 13. Round | 13/12/2021 | Anorthosis Famagusta | - | Doxa Katokopias | 2:0 | |
France