| 6. Round | 13/02/2022 | Santa Fe | - | Deportivo Pereira | 1:2 | ||||
| 11. Round | 17/03/2022 | Deportivo Pasto | - | Santa Fe | 2:4 | ||||
| 12. Round | 22/03/2022 | Santa Fe | - | Atlético Bucaramanga | 3:1 | ||||
| 13. Round | 29/03/2022 | Atlético Nacional | - | Santa Fe | 2:1 | ||||
| 14. Round | 04/04/2022 | Santa Fe | - | Unión Magdalena | 1:0 |  |
|||
| 15. Round | 10/04/2022 | Envigado FC | - | Santa Fe | 1:0 | ||||
| 16. Round | 16/04/2022 | Santa Fe | - | Alianza Petrolera | 0:1 |  |
Colombia