| 1. Round | 18/01/2021 | Defensor Sporting | - | Montevideo Wanderers | 1:1 | ||||
| 2. Round | 28/01/2021 | Peñarol | - | Defensor Sporting | 1:2 | ||||
| 3. Round | 01/02/2021 | Defensor Sporting | - | River Plate | 0:2 | ||||
| 4. Round | 04/02/2021 | Montevideo City Torque | - | Defensor Sporting | 0:0 | ||||
| 5. Round | 07/02/2021 | Defensor Sporting | - | Plaza Colonia | 3:2 | ||||
| 6. Round | 11/02/2021 | Progreso | - | Defensor Sporting | 3:3 | ||||
| 7. Round | 15/02/2021 | Defensor Sporting | - | Fénix | 2:2 | ||||
| 8. Round | 18/02/2021 | CA Cerro | - | Defensor Sporting | 0:0 |  |
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| 9. Round | 20/02/2021 | Defensor Sporting | - | Liverpool | 0:3 | |
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| 10. Round | 28/02/2021 | Defensor Sporting | - | Danubio | 1:1 | ||||
| 12. Round | 12/03/2021 | Defensor Sporting | - | Boston River | 1:2 | ||||
| 13. Round | 18/03/2021 | Deportivo Maldonado | - | Defensor Sporting | 2:1 | ||||
| 14. Round | 25/03/2021 | Defensor Sporting | - | Rentistas | 0:0 | ||||
| 15. Round | 29/03/2021 | Cerro Largo | - | Defensor Sporting | 0:0 |
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