| 1. Round | 01/08/2021 | Once Municipal | - | CD Águila | 2:2 | ||||
| 3. Round | 11/08/2021 | Once Municipal | - | Municipal Limeño | 4:1 | ||||
| 6. Round | 25/08/2021 | Luis Ángel Firpo | - | Once Municipal | 2:2 | ||||
| 7. Round | 29/08/2021 | AD Chalatenango | - | Once Municipal | 1:2 | ||||
| 5. Round | 10/09/2021 | Alianza | - | Once Municipal | 1:0 |  |
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| 12. Round | 03/10/2021 | CD Águila | - | Once Municipal | 1:2 | ||||
| 13. Round | 17/10/2021 | Once Municipal | - | Jocoro FC | 2:2 | ||||
| 15. Round | 24/10/2021 | Once Municipal | - | Platense Zacatecoluca | 1:1 | ||||
| 16. Round | 30/10/2021 | Once Municipal | - | Alianza | 2:3 | ||||
| 17. Round | 02/11/2021 | Once Municipal | - | Luis Ángel Firpo | 1:0 | ||||
| 18. Round | 07/11/2021 | Once Municipal | - | AD Chalatenango | 1:2 |  |
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| 19. Round | 14/11/2021 | FAS | - | Once Municipal | 3:2 | ||||
| 20. Round | 18/11/2021 | Once Municipal | - | Isidro Metapán | 1:1 | ||||
| 22. Round | 27/11/2021 | Once Municipal | - | Santa Tecla FC | 4:3 |
El Salvador