| 6. Round | 13/08/2021 | Mannucci | - | Deportivo Binacional | 3:1 | ||||
| 7. Round | 17/08/2021 | Cusco FC | - | Mannucci | 2:3 | ||||
| 9. Round | 28/08/2021 | Alianza Atlético | - | Mannucci | 2:0 | ||||
| 10. Round | 12/09/2021 | Mannucci | - | Universidad Técnica | 1:3 | ||||
| 11. Round | 18/09/2021 | Mannucci | - | Alianza Universidad | 1:1 | ||||
| 12. Round | 22/09/2021 | Sporting Cristal | - | Mannucci | 1:3 |  |
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| 13. Round | 25/09/2021 | Mannucci | - | Cienciano | 1:3 | ||||
| 14. Round | 01/10/2021 | Ayacucho FC | - | Mannucci | 3:2 | ||||
| 15. Round | 16/10/2021 | Mannucci | - | Alianza Lima | 0:1 | |
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| 16. Round | 22/10/2021 | Sport Boys | - | Mannucci | 3:3 | |
Peru