| 4. Round | 23/08/2021 | UNAN Managua | - | Real Madriz | 3:5 | ||||
| 5. Round | 30/08/2021 | CD Walter Ferretti | - | UNAN Managua | 1:1 | ||||
| 6. Round | 02/09/2021 | Real Estelí FC | - | UNAN Managua | 4:1 | ||||
| 10. Round | 02/10/2021 | UNAN Managua | - | Diriangén FC | 0:5 | ||||
| 12. Round | 18/10/2021 | ART Municipal Jalapa | - | UNAN Managua | 2:2 | ||||
| 15. Round | 31/10/2021 | Managua FC | - | UNAN Managua | 3:0 | ||||
| 17. Round | 18/11/2021 | UNAN Managua | - | Club Deportivo Ocotal | 2:3 | ||||
| 18. Round | 21/11/2021 | Juventus Managua | - | UNAN Managua | 1:2 |  |
Nicaragua