| 1. Round | 22/01/2022 | Diriangén FC | - | UNAN Managua | 4:0 | ||||
| 2. Round | 07/02/2022 | H&H Export Sébaco | - | UNAN Managua | 1:1 | ||||
| 3. Round | 09/02/2022 | UNAN Managua | - | ART Municipal Jalapa | 0:0 | ||||
| 4. Round | 13/02/2022 | Real Madriz | - | UNAN Managua | 0:1 | ||||
| 6. Round | 28/02/2022 | Managua FC | - | UNAN Managua | 3:3 | ||||
| 13. Round | 07/04/2022 | UNAN Managua | - | Real Madriz | 3:1 | ||||
| 15. Round | 14/04/2022 | UNAN Managua | - | Real Estelí FC | 0:0 |
Nicaragua