| 1. Round | 01/08/2021 | Real Estelí FC | - | H&H Export Sébaco | 4:0 | ||||
| 4. Round | 22/08/2021 | H&H Export Sébaco | - | Managua FC | 0:0 | ||||
| 8. Round | 19/09/2021 | Diriangén FC | - | H&H Export Sébaco | 1:0 | ||||
| 9. Round | 26/09/2021 | Real Madriz | - | H&H Export Sébaco | 3:3 | ||||
| 10. Round | 02/10/2021 | H&H Export Sébaco | - | Real Estelí FC | 1:3 | ||||
| 11. Round | 10/10/2021 | H&H Export Sébaco | - | UNAN Managua | 1:1 | ||||
| 18. Round | 20/11/2021 | H&H Export Sébaco | - | Real Madriz | 2:3 |
Nicaragua