| 10. Round | 04/09/2022 | Juventus Managua | - | H&H Export Sébaco | 1:1 |  |
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| 11. Round | 11/09/2022 | H&H Export Sébaco | - | CD Walter Ferretti | 1:1 | ||||
| 12. Round | 03/10/2022 | Real Estelí FC | - | H&H Export Sébaco | 3:1 | ||||
| 13. Round | 23/10/2022 | H&H Export Sébaco | - | Matagalpa FC | 2:1 | ||||
| 14. Round | 27/10/2022 | UNAN Managua | - | H&H Export Sébaco | 0:0 | ||||
| 15. Round | 30/10/2022 | H&H Export Sébaco | - | Club Deportivo Ocotal | 2:0 | ||||
| 16. Round | 24/11/2022 | Managua FC | - | H&H Export Sébaco | 0:1 | |
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| 17. Round | 27/11/2022 | H&H Export Sébaco | - | Diriangén FC | 0:3 | ||||
| 18. Round | 30/11/2022 | H&H Export Sébaco | - | ART Municipal Jalapa | 1:0 |
Nicaragua