| 1. Round | 07/02/2022 | River Plate | - | Montevideo Wanderers | 1:1 |  |
|||
| 2. Round | 14/02/2022 | Montevideo Wanderers | - | Cerro Largo | 1:0 | ||||
| 3. Round | 20/02/2022 | Fénix | - | Montevideo Wanderers | 0:3 | ||||
| 4. Round | 26/02/2022 | Montevideo Wanderers | - | Defensor Sporting | 1:0 | ||||
| 5. Round | 13/03/2022 | Albion | - | Montevideo Wanderers | 1:1 | ||||
| 6. Round | 20/03/2022 | Montevideo Wanderers | - | Nacional | 2:2 |  |
|||
| 8. Round | 11/04/2022 | Montevideo Wanderers | - | Deportivo Maldonado | 0:1 | ||||
| 9. Round | 18/04/2022 | Rentistas | - | Montevideo Wanderers | 1:3 | |
|||
| 10. Round | 23/04/2022 | Montevideo Wanderers | - | Liverpool | 0:0 | ||||
| 11. Round | 08/05/2022 | Peñarol | - | Montevideo Wanderers | 1:0 | ||||
| 12. Round | 15/05/2022 | Montevideo Wanderers | - | Montevideo City Torque | 1:1 | ||||
| 13. Round | 22/05/2022 | Cerrito | - | Montevideo Wanderers | 0:2 | ||||
| 14. Round | 29/05/2022 | Plaza Colonia | - | Montevideo Wanderers | 1:0 | |
Uruguay