| 3. Round | 27/01/2022 | Luis Ángel Firpo | - | Isidro Metapán | 0:0 | ||||
| 5. Round | 06/02/2022 | Once Municipal | - | Isidro Metapán | 0:0 | ||||
| 8. Round | 20/02/2022 | Isidro Metapán | - | FAS | 1:1 | ||||
| 16. Round | 10/04/2022 | Isidro Metapán | - | Once Municipal | 2:2 |  |
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| 17. Round | 14/04/2022 | CD Águila | - | Isidro Metapán | 1:3 | |
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| 18. Round | 17/04/2022 | Isidro Metapán | - | Jocoro FC | 3:0 | |
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| 19. Round | 24/04/2022 | FAS | - | Isidro Metapán | 4:1 | ||||
| 20. Round | 28/04/2022 | Isidro Metapán | - | Santa Tecla FC | 0:0 | ||||
| 21. Round | 01/05/2022 | Municipal Limeño | - | Isidro Metapán | 1:0 | ||||
| 22. Round | 07/05/2022 | Isidro Metapán | - | Atlético Marte | 1:1 |
El Salvador