| 1. Round | 31/07/2021 | Diriangén FC | - | UNAN Managua | 2:1 | ||||
| 2. Round | 10/08/2021 | UNAN Managua | - | H&H Export Sébaco | 0:2 | ||||
| 3. Round | 15/08/2021 | UNAN Managua | - | ART Municipal Jalapa | 1:0 | ||||
| 4. Round | 23/08/2021 | UNAN Managua | - | Real Madriz | 3:5 | ||||
| 5. Round | 30/08/2021 | CD Walter Ferretti | - | UNAN Managua | 1:1 | ||||
| 6. Round | 02/09/2021 | Real Estelí FC | - | UNAN Managua | 4:1 | ||||
| 7. Round | 13/09/2021 | UNAN Managua | - | Managua FC | 2:3 |  |
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| 8. Round | 20/09/2021 | Club Deportivo Ocotal | - | UNAN Managua | 1:2 | ||||
| 9. Round | 27/09/2021 | UNAN Managua | - | Juventus Managua | 1:1 | ||||
| 10. Round | 02/10/2021 | UNAN Managua | - | Diriangén FC | 0:5 | ||||
| 11. Round | 10/10/2021 | H&H Export Sébaco | - | UNAN Managua | 1:1 | ||||
| 12. Round | 18/10/2021 | ART Municipal Jalapa | - | UNAN Managua | 2:2 | ||||
| 13. Round | 22/10/2021 | Real Madriz | - | UNAN Managua | 0:1 | ||||
| 14. Round | 25/10/2021 | UNAN Managua | - | CD Walter Ferretti | 0:1 | ||||
| 15. Round | 31/10/2021 | Managua FC | - | UNAN Managua | 3:0 |  |
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| 16. Round | 04/11/2021 | UNAN Managua | - | Real Estelí FC | 3:3 | ||||
| 17. Round | 18/11/2021 | UNAN Managua | - | Club Deportivo Ocotal | 2:3 |
Costa Rica