| 1. Round | 24/01/2021 | Chinandega | - | Diriangén FC | 0:3 | ||||
| 2. Round | 28/01/2021 | Chinandega | - | Real Estelí FC | 2:4 | ||||
| 3. Round | 31/01/2021 | Chinandega | - | Managua FC | 1:1 | ||||
| 4. Round | 04/02/2021 | Club Deportivo Ocotal | - | Chinandega | 0:0 | ||||
| 5. Round | 06/02/2021 | Junior Managua | - | Chinandega | 2:1 | ||||
| 7. Round | 14/02/2021 | Juventus Managua | - | Chinandega | 1:3 | ||||
| 8. Round | 18/02/2021 | Chinandega | - | ART Municipal Jalapa | 1:1 |  |
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| 12. Round | 01/04/2021 | Managua FC | - | Chinandega | 3:1 | ||||
| 13. Round | 11/04/2021 | Chinandega | - | Club Deportivo Ocotal | 2:1 |  |
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| 14. Round | 18/04/2021 | Chinandega | - | Junior Managua | 2:1 | ||||
| 15. Round | 25/04/2021 | Real Madriz | - | Chinandega | 2:0 | ||||
| 16. Round | 29/04/2021 | Chinandega | - | Juventus Managua | 0:0 | ||||
| 17. Round | 03/05/2021 | ART Municipal Jalapa | - | Chinandega | 1:1 | ||||
| 18. Round | 05/05/2021 | Chinandega | - | CD Walter Ferretti | 0:3 |
Nicaragua