6. Round | 25/08/2021 | Platense Zacatecoluca | - | Isidro Metapán | 2:1 | ||||
7. Round | 29/08/2021 | Isidro Metapán | - | Alianza | 1:2 | ||||
8. Round | 12/09/2021 | Luis Ángel Firpo | - | Isidro Metapán | 1:1 | ||||
10. Round | 19/09/2021 | FAS | - | Isidro Metapán | 3:0 | ||||
12. Round | 02/10/2021 | Atlético Marte | - | Isidro Metapán | 2:0 | ||||
13. Round | 17/10/2021 | Isidro Metapán | - | Santa Tecla FC | 1:1 | ||||
14. Round | 21/10/2021 | CD Águila | - | Isidro Metapán | 4:0 | ||||
21. Round | 21/11/2021 | Isidro Metapán | - | FAS | 1:2 | ||||
22. Round | 27/11/2021 | AD Chalatenango | - | Isidro Metapán | 1:0 |