| 1. Round | 16/08/2021 | Newcastle United U23 | - | Reading FC U23 | 1:1 | ||||
| 2. Round | 23/08/2021 | Reading FC U23 | - | Wolverhampton Wanderers U23 | 3:0 | ||||
| 18. Round | 24/01/2022 | Aston Villa U23 | - | Reading FC U23 | 4:1 | ||||
| 21. Round | 28/02/2022 | Wolverhampton Wanderers U23 | - | Reading FC U23 | 4:3 | ||||
| 15. Round | 06/03/2022 | Birmingham City U23 | - | Reading FC U23 | 0:0 | ||||
| 22. Round | 14/03/2022 | Reading FC U23 | - | Burnley FC U23 | 2:1 | ||||
| 24. Round | 01/04/2022 | Reading FC U23 | - | West Bromwich Albion U23 | 1:1 | ||||
| 25. Round | 25/04/2022 | Reading FC U23 | - | Fulham FC U23 | 3:1 | ||||
| 26. Round | 01/05/2022 | Middlesbrough FC U23 | - | Reading FC U23 | 2:1 |  |
Ireland