| 1. Round | 14/08/2021 | Floriana FC | - | St. Luċija FC | 2:2 | ||||
| 2. Round | 22/08/2021 | St. Luċija FC | - | Gżira United | 1:1 | ||||
| 3. Round | 12/09/2021 | Gudja United | - | St. Luċija FC | 2:2 | ||||
| 4. Round | 18/09/2021 | St. Luċija FC | - | Sirens FC | 1:3 | ||||
| 5. Round | 25/09/2021 | Hibernians FC | - | St. Luċija FC | 1:1 | ||||
| 6. Round | 17/10/2021 | St. Luċija FC | - | Mosta FC | 2:2 | ||||
| 7. Round | 24/10/2021 | St. Luċija FC | - | Sliema Wanderers | 0:0 |  |
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| 8. Round | 30/10/2021 | Valletta FC | - | St. Luċija FC | 5:3 | ||||
| 9. Round | 21/11/2021 | St. Luċija FC | - | Birkirkara FC | 2:0 | ||||
| 10. Round | 28/11/2021 | Hamrun Spartans | - | St. Luċija FC | 3:0 | ||||
| 11. Round | 05/12/2021 | St. Luċija FC | - | Balzan FC | 3:3 | |
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| 14. Round | 19/01/2022 | St. Luċija FC | - | Gudja United | 0:3 | ||||
| 16. Round | 29/01/2022 | St. Luċija FC | - | Hibernians FC | 0:0 | ||||
| 17. Round | 05/02/2022 | Mosta FC | - | St. Luċija FC | 1:0 |
Malta