| 1. Round | 22/08/2021 | Olympiakos Nikosia | - | Aris Limassol | 1:2 | ||||
| 2. Round | 13/09/2021 | APOEL Nikosia | - | Olympiakos Nikosia | 0:1 | ||||
| 3. Round | 18/09/2021 | Olympiakos Nikosia | - | AEL Limassol | 1:1 | ||||
| 4. Round | 27/09/2021 | AEK Larnaca | - | Olympiakos Nikosia | 1:0 | ||||
| 5. Round | 03/10/2021 | Olympiakos Nikosia | - | Omonia Nikosia | 1:0 | ||||
| 6. Round | 16/10/2021 | Paphos FC | - | Olympiakos Nikosia | 1:1 | ||||
| 7. Round | 22/10/2021 | Olympiakos Nikosia | - | Doxa Katokopias | 1:0 |  |
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| 8. Round | 31/10/2021 | Olympiakos Nikosia | - | Apollon Limassol | 0:2 | ||||
| 9. Round | 05/11/2021 | PAEEK | - | Olympiakos Nikosia | 0:0 | ||||
| 10. Round | 20/11/2021 | Olympiakos Nikosia | - | Anorthosis Famagusta | 3:2 | ||||
| 11. Round | 26/11/2021 | Ethnikos Achna | - | Olympiakos Nikosia | 1:0 | ||||
| 12. Round | 03/12/2021 | Aris Limassol | - | Olympiakos Nikosia | 1:0 | ||||
| 13. Round | 12/12/2021 | Olympiakos Nikosia | - | APOEL Nikosia | 1:1 | ||||
| 14. Round | 19/12/2021 | AEL Limassol | - | Olympiakos Nikosia | 3:0 | ||||
| 16. Round | 10/01/2022 | Omonia Nikosia | - | Olympiakos Nikosia | 1:0 |
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