| 2. Round | 20/03/2021 | FK Minsk | - | Rukh Brest | 2:2 |  |
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| 5. Round | 18/04/2021 | Rukh Brest | - | FK Smorgon | 5:0 | ||||
| 6. Round | 25/04/2021 | Shakhter Soligorsk | - | Rukh Brest | 4:1 | ||||
| 7. Round | 30/04/2021 | Rukh Brest | - | FK Slaviya Mozyr | 2:1 | ||||
| 8. Round | 08/05/2021 | Rukh Brest | - | Sputnik Rechytsa | 2:0 | ||||
| 9. Round | 15/05/2021 | BATE Borisov | - | Rukh Brest | 3:2 | ||||
| 12. Round | 13/06/2021 | Rukh Brest | - | Torpedo-BelAZ Zhodino | 3:0 | ||||
| 13. Round | 19/06/2021 | FK Vitebsk | - | Rukh Brest | 0:0 | ||||
| 14. Round | 27/06/2021 | Rukh Brest | - | FK Slutsk | 1:0 | ||||
| 16. Round | 17/07/2021 | FK Gomel | - | Rukh Brest | 0:0 | ||||
| 17. Round | 23/07/2021 | Rukh Brest | - | FK Minsk | 1:0 | ||||
| 18. Round | 30/07/2021 | Energetik-BGU Minsk | - | Rukh Brest | 0:2 | ||||
| 27. Round | 24/10/2021 | Torpedo-BelAZ Zhodino | - | Rukh Brest | 3:3 | ||||
| 28. Round | 05/11/2021 | Rukh Brest | - | FK Vitebsk | 2:0 |
Belarus